Biome IQ is the only company with a product line pure enough and protocols specific enough to meet the needs of each MTHFR gene type.
These formulas work! They have been prescribed to MTHFR patients for nearly a decade with great results by the BodyScience medical group.
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MTHFR Test Kit

Test your Family at Home , The MTHFR Genetic Test is simple, reliable and the most effective way to test if you have MTHFR (Buccal Swab Test).

Detox P5.0 - The Perfect Solution To Get Rid Of Toxins

A Program Designed to Address the Most Common Underlying Causes of Chronic Health Challenges and MTHFR. 

MTHFR Maintenance Kits

 We are the first company to create genetically specific protocols based on MTHFR gene mutations.

BiomeIQ Catalog

Get some of our best sellers now and save even more!


 More than twice the bioavailability as oil-based/nano dispersed Cofactor-Q formulas for MTHFR enzyme reduction

Pure Methylation

Pure Methylation is the combination of 3 B Vitamins: B12, B6, and Folate, Recommended for individuals with MTHFR mutations.

Pure D3

Vitamin D3, highly absorbable and very pure
one single drop is 1000 units
Other Great Supplements
Ca D Glucarate Plus
Fast MTHFR Relief
Feel Full
Immune Balance 1
Pure Magnesium Chelate $35.99
Detox Shake P5.0
Detox 30 Pack
Digestive Enzymes
Pure Detox
Pure Detox 2
MTHFR Multi-Balance $43.99
Alos our NEW weight loss Supplements (MTHFR Approved)
Skinny Shake
A super B-complex designed for individuals with methylation deficiencies. Contains L-methylfolate for best bio-absorption. Contains 60 Vegetarian Capsules
Amy talks about MTHFR and PURE METHYLATION
TECH TALK! Amy explains how PURE METHYLATION works...
What does BiomeIQ’s Pure Methylation do and How Does it Work?

MTHFR mutations cause a deficiency in methylation, which creates the inability to make enough methylation to support the entire body. They also create difficulty producing the enzyme Folate Reductase at an efficient rate. Meaning: Your body gets dirty faster from a buildup of toxins. Most of the symptoms associated with MTHFR are not as a result of the mutation but because the body is overloaded with lots of toxins that cause hormone dysregulations and make you feel sick in general.

Common signs of toxicity within the body:
Inflammation ,  Chronic fatigue ,  Weight gain, Bloating, Foggy brain, Poor focus and concentration, Irregular/Painful periods, Low energy, Skin problems, Anxiety, Nausea, Headaches
How do you get rid of the toxins and make up for the methylation difficulty?
You can take methylation in the form of a handful of B vitamins, because the mutation is not just affecting methyl groups but also the enzyme Folate Reductase which methylate’s Folate. Pure Methylation is the combination of 3 B Vitamins: B12, B6, and Folate.

Why do a balanced B? If what you need is folate and you need it to be methylated, then why add a B12 and a B6?

Bodies work in ratios. They aren’t designed to work on a single B vitamin or any single nutrient for that matter. Think about foods with lots of B vitamins such as leafy green vegetables. You never find just one B vitamin, and this is because the mitochondrial cycle requires a number of B’s in a very specific ratio. Therefore, we use Pure Methylation in our clinic and recommend it to individuals with MTHFR mutations. Pure Methylation is the combination of 3 B Vitamins: B12, B6, and Folate and adheres to the same ratio that the mitochondrial cycle prefers with the already reduced form of the vitamin folate. This means it’s easy to absorb if you have MTHFR mutations.

Additional benefits of Pure Methylation:
• Supports neurological and cognitive health
• Supports the upkeep of healthy homocysteine levels
• Twice the amount of bioavailability
• Supports healthy methylation
• Supports a healthy heart

Keep in mind; methylation is a tool that the body uses to turn on and turn off reactions. It is a promoter, it turns on sequences. Do not with any methylation, including this product or any other supporting methylation, don’t take too much of it. If you over methylate, a whole bunch of different reactions in the body are created that can’t be controlled. 
The key when picking out a product concerning methylation is to make sure that its pure and certified specifically for MTHFR. MTHFR bodies DO NOT like toxicity. Make sure it is a very clean physician grade vitamin such as our Pure Methylation. You also want to make sure you have the right ratio of B vitamins. Just taking a methylated folate can be a problem because the mitochondrial cycle is turned on by B12. Only driving one part of this cycle without the rest can create problems for the body.
If you’re looking for a safe product for effective methylation with the right balance of B vitamins and a clean product that’s easily absorbable, then we recommend Pure Methylation.

A super B-complex designed for individuals with methylation deficiencies. Contains L-methylfolate for best bio-absorption. Contains 60 Vegetarian Capsules
Methylation3 is one of the best methyl donors for people with MTHFR
BiomeIQ - Ca D Glucarate Plus
Supports detoxification, deactivates toxins and promotes their elimination.
What does BiomeIQ’s Ca D Glucarate Plus?
Supports detoxification, deactivates toxins and promotes their elimination. D-glucarate plays a vital protective role for the immune system by inhibiting the beta-glucuronidase enzyme that can otherwise interfere with safe removal of steroid hormones such as estrogen which can be reduced by MTHFR mutations. Contains 120 capsules.

Symptoms of Estrogen Dominance:
Missed periods , Periods too frequently, Excessive cramps and clotting during period, Fertility difficulties, PCOS 
BiomeIQ MTHFR Supplements - METHYLATION3
The Plus portion of this supplement means that in addition to Glucarate which will bind and reduce Glucuronidase, there’s also Super Oxide Dismutase, which is one of the strongest antioxidants. MTHFR mutations oftentimes trigger inflammation. It’s a methylation deficiency so toxins aren’t removed effectively, and these toxins lead to inflammation. Our Calcium D Glucarate plus not only gets Estrogen Dominance under control, but it also adds in Super Oxide Dismutase which reduces inflammation.
If you’re a woman with fertility, estrogen-progesterone, period related issues, this supplement might be for you
BiomeIQ - PURE D3
A liquid vitamin D and sunflower oil formula microemulsified for the type of maximum absorption required with MTHFR mutations.
Amy talks about MTHFR and PURE D3
TECH TALK! Amy explains how PURE D3 works...
When living with MTHFR mutations, it’s necessary when choosing supplements that they are easily absorbable, pure, and clean of unnecessary ingredients. Our Pure D3 is a medical grade vitamin D supplement which is highly absorbable and designed to be pure and free of toxic ingredients. A little goes a long way with this product, 1 single drop out of this D3 equals 1,000 units, and there are 1,500 (or 750) drops in each bottle, making it very easy to find the dosing needed.

Vitamin D is essential for maintaining a healthy gut, and aids in repairing damaged tissues and cells within the body. As Vitamin D levels rise, it begins to function as a vitamin, meaning it starts turning on and off reactions and is critical to many necessary reactions. When living with MTHFR mutations, the immune system needs to be strong due to the buildup of toxins that distract the immune system from other threats. Vitamin D supports the immune system and having Vitamin D3 as an immune modulator, is essential for optimal gut health.

Remember: Vitamin D is a fat-soluble vitamin and needs to be taken with healthy fatty foods (avocados, almonds, olive oil). You’ll get a much better result when this vitamin is taken with fat.

Benefits of Vitamin D3:

 Support and maintain a healthy immune system , Reduce inflammation, Heals gut dysbiosis, Repairs tissues and damages within the gut, Reduce Auto-immunity, Improves brain function, Improves mood and sleep, Supports calcium absorption and healthy bones, Supports heart health and lood pressure regulation, Supports dental health 
BiomeIQ MTHFR Supplements - Pure D3
A liquid vitamin D and sunflower oil formula microemulsified for the type of maximum absorption required with MTHFR mutations. Each drop contains 1000IU of highly purified D3 liquid as cholecalciferol. Contains 30 or 60mL.
Pure D3 - 1oz - 30mL
Pure D3 - 2.03oz - 60mL
More than twice as bioavailable as oil-based/nano dispersed Cofactor-Q formulas to meet the metabolic needs of MTHFR enzyme reduction
Amy talks about MTHFR and PURE COQ100
TECH TALK!, Amy explains how PURE COQ100 works...
Pure COQ100 is a medical grade version of COQ10 and it’s pure enough to meet the requirements of someone who has MTHFR. COQ10 is a critical co factor to running the metabolic cycle. The metabolic cycle takes place within the mitochondria and this cycle is the main producer of our energy and our detoxifiers. The mitochondrial cycle has three main cofactors that are needed to support the process of energy production. The beginning stage of the cycle relies on vitamin B12, the middle stage relies on a specific form of COQ10, and the last stage relies on using Folate Reductase to reduce the vitamin Folate.

COQ10 is an essential step in the cycle, which is why it’s important to make sure your body is getting enough of it.

Signs of a COQ10 deficiency:
Chronic Fatigue , Chronic Pain, Exhaustion, Low Energy, Brain fog, Lack of focus/concentration, High blood pressure 
BiomeIQ MTHFR Supplements - Pure CoQ100
Why we recommend Pure COQ: 
Supports energy production and boosts energy levels , Aids in mitochondrial function, Supports the production and breakdown of neurotransmitters, Supports heart health, Supports the nervous system, Supports the immune system, Supports healthy aging, Reduces Free Radicals, Reduces inflammation
More than twice as bioavailable as oil-based/nano dispersed Cofactor-Q formulas to meet the metabolic needs of MTHFR enzyme reduction* Contains 30 or 60 Softgels
BiomeIQ - Fast MTHFR Relief
Do you often experience foggy brain after eating lunch? Do you develop a headache after smelling certain scents? BiomeIQ’s Fast MTHFR Relief is perfect for fast relief of MTHFR symptoms. This supplement contains the necessary ratio of Methylfolate and Methyl B12 allowing the methylation system to work more efficiently and produce methyl groups. 
BiomeIQ MTHFR Supplements - Fast MTHFR Relief
Benefits of Fast MTHFR Relief: 
  • Supports healthy Methylation 
  • Supports a healthy nervous system 
  • Supports optimal health for pregnancy  
  • Supports healthy cell production 
  • Supports healthy neurotransmitter production 
  • Supports a healthy brain 
  • Supports a healthy sleep cycle
Common MTHFR symptoms:
  • Foggy brain 
  • Fatigue 
  • Headaches 
  • Chronic aches and pain 
  • Insomnia and sleep problems 
  • Depression 
  • Anxiety
Chewable fast-acting folate and B12, methylated specifically for use with MTHFR mutations. Fast acting and great to keep in your bag for quick relief.
BiomeIQ - Feel FULL!
BiomeIQ’s Feel Full provides the natural dietary fiber needed to support bowel regularity. Feel Full, a prebiotic clinically proven to reduce sugar and hormonal imbalances, allows the body to feel full and satisfied, meaning you eat less. 
As a prebiotic, this supplement not only regulates bowel movements but also eases them. In addition, it’s in powder form making it easy for ingestion and digestion. Just one scoop before a meal will trigger the feeling of fullness. This natural dietary fiber easily absorbs water within the digestive tract and is one of the best viscous dietary fibers known.

Viscosity is a characteristic of soluble fiber that indicates the fibers ability to thicken when mixed with fluids. Not only is Feel Full viscous but it’s also stable, allowing for the fiber to remain in tact as it moves throughout the digestive system. Soluble fiber also reduces cholesterol and fat absorption, as well as carries out bile from the intestines.

BiomeIQ MTHFR Supplements - Feel Full
Benefits of Feel Full: 
  • Supports healthy weight control
  • Reduces sugar and hormonal imbalances 
  • Supports healthy and regular bowel movements 
  • Supports glucose and lipid metabolization 
  • Helps the body feel full  
  • Supports optimal health and wellness  
  • Prebiotic
1 scoop before meals triggers fullness. Clinically proven soluble fiber and prebiotic reduces hormone and sugar imbalances while supporting healthy bowel movements*
BiomeIQ - Immune Balance 1
Aids in maintaining a healthy gut and is a preventive step for autoimmune diseases.
Do you have a low immune system? Get sick often? Want to add some extra immune protection for cold and flu season? Or back to school? Biome IQ’s Immune Balance 1 helps support and protect the immune system. By adding immunoglobulins and active proteins into the body, Immune Balance 1 aids in maintaining a healthy gut and is a preventive step for autoimmune diseases. 

BiomeIQ MTHFR Supplements - Immune Balance 1
Symptoms of a poor immune system:
  • Constantly getting sick/ repeat infections
  • Autoimmune diseases such as arthritis, lupus 
  • Inflammation 
  • Digestive problems such as diarrhea or constipation 
  • Fatigue 
  • Allergies 
  • Fever 
  • Rash 
  • Joint pain 
  • Leaky Gut
Immunoglobulin’s work to remove toxins and unwanted molecules within the gut and provides a healthier environment. As toxins move throughout the body, immunoglobulins flag unwanted invaders informing the immune system, and allow for efficient elimination of the toxins. In addition, Immune Balance 1 protects the gut tissue preventing toxins from attaching onto the tissue. One of the active ingredients, Lactoferrin, contain growth factors resulting in regenerating healthy cell growth in the gut to strengthen the gut lining, slows the breakdowns of proteins, and helps rebuild muscle mass.

Immune Balance 1 also supports healthy brain development, helping to maintain cognitive and neurological health during aging, and alleviating cytotoxicity within neurons. One of the bioactive compounds, Oligosaccharides, regulate gut microbiota by attracting toxins and preventing them from attaching to epithelial surfaces of the intestine. In addition, beneficial bacteria growth is promoted aiming to restore the balance of healthy good bacteria within the gut.

Immune Balance 1 aims to enhance your quality of life by preventing frequent infections, strengthening the immune system, and ultimately increasing your ability to enjoy day to day activities without feeling ill

Benefits of Immune Balance 1:
  • Supports a healthy immune system
  • ​Repairs gut tissue 
  • ​Supports gut repair pathways within the body 
  • ​Supports optimal health and wellness 
  • ​Supports healthy cell growth 
  • ​Aids in detoxification 
  • ​Supports optimal brain development 
  • ​Improves exercise performance 
BiomeIQ - Pure Magnesium Chelate
Magnesium is necessary in creating a healthy gut environment and essential for optimal health and wellness.
Are you deficient in Magnesium? Have you been experiencing leg cramps, anxiety, high blood pressure, or the inability to fall asleep at night? BiomeIQ’s Pure Magnesium Chelate is a fast-acting powder form of Magnesium Glycinate that is easily dissolved into water or juice for the best bio-availability. Our chelated form allows for the Magnesium to easily enter the body and to remain intact as it makes its way from the stomach to the small intestines, resulting in more Magnesium absorption than a non-chelated version.  

Symptoms of Magnesium Deficiency:
  • Muscle cramps/spasms
  • Osteoporosis 
  • Chronic Fatigue/Exhaustion 
  • Muscle Weakness 
  • High Blood Pressure
  • Allergies/Asthma 
  • Arrhythmia 
  • Anxiety 
  • Insomnia 
Magnesium is necessary in creating a healthy gut environment and essential for optimal health and wellness. We use Magnesium Glycinate because it is one of the best absorbed forms of magnesium and is easy on the stomach making it less likely to cause gut distress or laxative effects. Adding two scoops of Pure Magnesium Chelate into your water daily, can help to reduce anxiety, and maintain a healthy heart. 

Having trouble sleeping? Add a couple scoops of BiomeIQ’s Pure Magnesium Chelate into your bath, in the evening an hour or two before bed. The Magnesium will absorb through the skin, and your body will feel the effects rather quickly. Magnesium helps the brain feel relaxed and calm, reducing anxiety provoking thoughts and allowing the body to feel relaxed and at ease. 
Benefits of Pure Magnesium Chelate:
  • Supports healthy blood pressure
  •  Supports sugar breakdown 
  •  Supports healthy bone development 
  •  Reduces headache frequency 
  •  Supports healthy sleep  
  •  Supports neurological and cognitive health 

BiomeIQ MTHFR Supplements - Pure Magnesium Chelate
BiomeIQ - MTHFR Multi Balance
packed full of the essential vitamins, minerals, and anti-oxidants necessary for individuals with MTHFR Mutations.
Benefits of MTHFR Multi Balance:
  • Supports the immune system
  •  Reduces frequency of illness 
  •  Supports healthy tissue and collagen growth 
  •  Supports healthy skin 
  •  Gentle on the stomach 
  •  Antioxidant 
  •  Reduces Oxidative stress and free radical damage 
  •  Supports healthy bones 
  •  Supports digestive system 
BiomeIQ MTHFR Supplements - MTHFR Multi-Balance
BiomeIQ’s MTHFR Multi-Balance is packed full of the essential vitamins, minerals, and anti-oxidants necessary for individuals with MTHFR Mutations. Looking to stay protected from sicknesses throughout the year? Vitamin C is essential for a healthy immune system, producing healthy levels of collagen and connective tissue, supporting the adrenals, and reducing the frequency of illness. Vitamin C also benefits healthy skin, improving acne, and reducing redness. 

Some multi vitamins can be rough on the stomach but MTHFR Multi-Balance has added Calcium, Magnesium, and Potassium, making this supplement easy on the stomach. The added calcium brings additional benefits such as supporting healthy and strong bones, muscles, and protects the heart. MTHFR Multi Balance also contains Zinc, Manganese, and copper in bioavailable forms for the body. Zinc is a mineral that helps fights colds and reduces symptoms. 

Quercetin, a potent antioxidant and bio-flavonoid, fights against free radical damage and prevents oxidative stress. Quercetin is anti-inflammatory and helps manage heart disease, infections, allergies, autoimmune symptoms, and chronic fatigue. Reduced L-Glutathione, which is in the most bio-available form, also supports a healthy immune system and is an anti-aging antioxidant. In addition, it’s a heavy metal chelator which allows for more frequent elimination of heavy metals and toxins. 
BiomeIQ - MTHFR Detox Individual Products
Degistive Enzymes I & 2
Pure Detox and Pure Detox 2
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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease