Do you know if you have MTHFR?
MTHFR, is the most asked-about gene by 23andMe customers.
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MTHFR Genetic Test Kit
Signs of MTHFR: Irregular periods , Migraines, Cold hands, Hot flashes, Weight gain/Bloating, Foggy brain, Poor focus and concentration, Fatigue, Low energy, Skin problems, Anxiety, Nausea, Inflammation 
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"BiomeIQ’s MTHFR Genetic Test Kit was very easy to use! A cheek swab is used to collect the saliva, making it very easy to test my two kids. I received our results quickly and was surprised at how easy to understand the results were. I highly recommend this test kit." - Heather
"Since I purchased my MTHFR Genetic Test, I’ve learned more about my MTHFR mutations. The testing process was easy, and after receiving my results I spoke with an MTHFR Expert who helped me understand my results. This knowledge has helped me to reduce my symptoms and start feeling energized and motivated again." -Penny
"The experience I had with the Genetic Test Kit was very positive. Testing was user friendly and easy to do. The results came back quickly and gave easy to understand and relevant information about my MTHFR mutation. Now, it’s time to test the rest of my family!" -Sue
Test your Family at Home
The MTHFR Genetic Test is simple, reliable and the most effective way to test if you have MTHFR
Buccal Swab Test NOW $149.00 $129.00
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Buccal Swab Tests Differences
Tests for MTHFR A1298C and MTHFR C677T. This test explains which specific MTHFR mutation you have, and whether you are heterozygous (1 mutation), homozygous (2 mutations), or compound heterozygous (1 copy of A1298C and 1 copy of C677T).

Tests for both MTHFR A1298C and MTHFR C677T, as well as COMT VAL158MET
If you have both COMT and MTHFR mutations, you are at an increased risk for feeling stressed and anxious. MTHFR mutations create a methylation deficiency. Methylation is essential for many body processes such as healthy neurotransmitter production and breakdown. Methyl groups help the body produce the adequate amounts of serotonin, dopamine, and adrenaline. With COMT mutations, you experience slower breakdown speeds of neurotransmitters, and with MTHFR mutations your body is producing less neurotransmitters or is unable to properly breakdown neurotransmitters. Having a combination of both of these mutations results in a predisposition to anxiety.

Tests for COMT VAL158MET.
Finding out whether or not a COMT mutation is affecting your neurotransmitter breakdown, can allow you to choose supplementation that will help improve your symptoms. For example, for individuals with COMT mutations, TMG (Betaine) is often the most effective choice in methyl donor. Methylated B vitamins are often over stimulatory when COMT mutations are involved. As well, they are promoters/co-factors for many other pathways which means they can cause a lot of undesirable reactions. Therefore, testing for this mutation can help you understand why your body reacts to certain vitamins in negative ways, and you can choose supplementation and nutrition that is right for your genes

Our test kit is minimally invasive, NO blood draw needed. Easy to use, convenient test that can be performed in the privacy of your home. Designed for all ages including infants. Tests for MTHFR A1298C and MTHFR C677T.


Both MTHFR and COMT genes are involved in the methylation pathway and testing their function is important to better understand your body’s functions such as:
Brain chemistry important for mood, anxiety, and stress
Immune function
Controlling inflammation
Energy production
Detoxification of chemicals and toxins
Cardiovascular health

The COMT (catechol-O-methyltransferase)gene codes for the essential COMT enzyme that is involved in the inactivation of catecholamines such as dopamine, epinephrine, norepinephrine, and catecholestrogens. 1-3 Scientific research has demonstrated that a common mutation in the COMT locus results in the replacement of the amino acid valine with methionine at position 158 in the enzyme. This causes a dramatic reduction in the enzyme’s ability to metabolize these neurotransmitters and catecholestrogens
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MTHFR gene mutations create blockages that don’t allow all the body’s toxins to become detoxified due to being slowed by unmetabolized folic acid. Since our bodies have a hard time converting folic acid to methyl-folate, the unmetabolized folic acid sits in our bodies and so do the toxins. Without the proper detoxification, our bodies tend to react to toxins in a negative way.

The MTHFR (methylenetetrahydrofolate reductase) gene produces an enzyme that helps in  processing folate and regulating homocysteine levels in the body. Folate is a critical nutrient involved  in methylation, DNA synthesis and amino acid metabolism. Impaired folate metabolism due to MTHFR enzyme inactivity, or a low folate level, results in elevated  plasma homocysteine.

Homocysteine is an amino acid synthesized by the body through demethylation of methionine. In the  presence of adequate B vitamins, homocysteine is either irreversibly degraded to cysteine or it is remethylated back to methionine, an essential amino acid. An elevated homocysteine level is known to be an independent risk factor for ischemic stroke, thrombotic and cardiovascular diseases. Folate,vitamin B6 or vitamin B12 are all necessary for the proper conversion of homocysteine into  methionine. A deficiency in any of these vitamins can cause homocysteine levels to rise.

Two single nucleotide variants known to affect MTHFR function are C677T (a change from cytosine to thymine at position 677 within the gene) and the A1298C mutation (a change from adenine to cytosine at position 1298 within the gene).It is not uncommon for some individuals to have both MTHFR variants. Clinical relevance for hyperhomocysteniemia is associated with homozygosity for C677T. In general, these genotypes produce MTHFR enzyme with reduced function and activity.
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Impaired folate metabolism due to reduced MTHFR enzyme activity, or decreased folate, results in elevated plasma homocysteine which has been linked to depression. There is no evidence to suggest that the A1298C mutation alone affects plasma homocysteine levels, however, it has been demonstrated that individuals who are compound heterozygotes for both the C677T and the A1298C mutations may have increased plasma homocysteine concentrations. Elevated homocysteine levels are inversely associated with memory score, and directly related to brain atrophy and depressive symptoms. Folate levels are directly related to memory scores, and inversely related to depressive symptoms in women. C677T T/T homozygous allele carriers are associated with a higher risk of depression, schizophrenia, and bipolar disorder as compared to the C/C genotype. Depressed, schizophrenic, and bipolar individuals showed a trend towards increased frequency of the T allele, therefore C/T heterozygous allele carriers may have an intermediate risk for depression. A1298C C/C homozygous allele carriers are reported to have an increased risk of depression and schizophrenia compared to homozygous A/A carriers, while A/C heterozygous allele carriers did not show an increased risk.
An elevated homocysteine level has been identified as an independent risk factor for ischemic stroke, thrombotic and cardiovascular diseases. However, it is important to remember that this is a multifactorial condition, involving a combination of genetic, physiologic, and environmental factors, and clinical relevance of MTHFR testing should be interpreted in light of clinical information.
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